To setup for multiple users:
1) Right-click on the Call of Duty 4 icon you use to start the game.
2) Select Properties.
3) In the Target field you'll see a line like "C:/Program Files/Activision/Call of Duty 4 - Modern Warfare/iw3mp.exe", add the net_port command to specify a unique communication port for each system. The complete field should look like this:
"C:/Program Files/Activision/Call of Duty 4 - Modern Warfare/iw3mp.exe" +set net_port 28960
4) Click OK.
5) Repeat for each system behind the NAT, adding one to the net_port selected (28961,28962,28963 etc.. )